UPLC-MS/MS and Dushman reaction based spectrophotometric method for determination of Ceftazidime, an antibiotic, in medicinal formulation
نویسندگان
چکیده
ABSTRACT: Two analytical methods were developed, one utilizing sensitive UPLC-MS/MS method while other being the spectrophotometric exploiting Dushman reaction. Both validated based on ICH guidelines and successfully applied to quantitate drug in marketed formulation. responded linearly range of 1.6 µgmL-1-6.4 µgmL-1 procedure followed Beer’s law concentration 30-100 µgmL-1. has been found have a limit quantitation 0.97 was 14.00 correctly with high precision. showed an excellent recovery 99.36%-100.91% (% RSD 1.05-1.73) 98.64%-99.73% (%RSD 0.67-1.68) for spectrophotometric, respectively.
منابع مشابه
development and implementation of an optimized control strategy for induction machine in an electric vehicle
in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولSpectrophotometric Determination of Corticosteroids and Its Application in Pharmaceutical Formulation
A simple, sensitive and economically viable spectrophotometric method for the determination of corticosteroids (predinsolone {PSL}, dexamethasone {DEX}, prednisone {PS}, betamethasone sodium phosphate {BEP} and hydrocortisone {HYD} has been developed. The method involves the oxidation of corticosteroids by iron (III) and subsequent complexation of iron (II) with potassium hexacynoferrate (III),...
متن کاملDerivative Spectrophotometric Method for Determination of Losartan in Pharmaceutical Formulations
Losartan, a highly effective blood pressure lowering agent, has been widely used for the treatment of hypertension. A fast and reliable method for the determination of losartan was highly desirable to support formulation screening and quality control. A first derivative UV spectroscopic method was developed for determination of losartan in the tablet dosage form. The first derivative spectrum r...
متن کاملapplication and construction of carbon paste modified electrodes developed for determination of metal ions in some real samples
ساخت الکترودهاِی اصلاح شده ِیکِی از چالشهاِی همِیشگِی در دانش شیمِی بوِیژه شیمِی تجزیه مِی باشد ،که با در نظر گرفتن سادگِی ساخت، کاربردی بودن و ارزان بودن روش مِی توان به باارزش بودن چنِین سنسورهاِی پِی برد.آنچه که در ادامه آورده شده به ساخت و کاربرد الکترودهاِی اصلاح شده با استفاده از نانو ذرات در اندازه گِیرِی ولتامترِی آهن وکادمِیم اشاره دارد. کار اول اختصاص دارد به ساخت الکترود خمِیر کربن اصلاح شده با لِیگاند داِ...
15 صفحه اولSPECTROPHOTOMETRIC REACTION RATE METHOD FOR THE DETERMINATION OF NITRITE BY CATALYTIC ACTION ON NILE BLUE A BROMATE REACTION
A kinetic method developed for the determination of ultra-trace amounts of nitrite based on its catalytic effect on the reaction between potassium bromate and Nile blue A in strongly acidic media is reported. The reaction was monitored spectrophotometrically by measuring the decrease in absorbance of Nile blue A at 645 nm by the fixed-time method. The decrease in absorbance during the first...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Food Science and Technology
سال: 2021
ISSN: ['2331-513X', '2331-5156']
DOI: https://doi.org/10.1590/fst.07020